Recombinant BRWD3 (1295-1443) protein
货号：
31443 基本售价：
5872.5 元 规格：
100 μg
产品信息
概述| 货号 | 31443 |
| 别名 | BRODL; MRX93 |
| 使用方法 | Recombinant BRWD3 (1295-1443) is suitable for use in binding assays, inhibitor screening, and selectivity profiling. |
性能| 供应商 | Active Motif |
| 背景 | Bromodomain and WD repeat domain containing 3 (BRWD3) is a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD) residues which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains a bromodomain and multiple WD repeats. The bromodomain functions as a ‘reader’ of epigenetic histone marks and regulates chromatin structure and gene expression by linking associated proteins to the recognized acetylated nucleosomal targets. Mutations in BRWD3 cause mental retardation X-linked type 93, which is also referred to as mental retardation X-linked with macrocephaly. This gene is also associated with translocations in patients with B-cell chronic lymphocytic leukemia (B-CLL). |
| 运输条件 | Dry Ice |
| 存放说明 | Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage. |
| 外观 | 100 µg of recombinant BRWD3 (1295-1443) protein expressed in E. coli at a concentration of 2.9 mg/ml in 25 mM HEPES pH 7.5, 150 mM NaCl and 5% glycerol. |
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参考图片Recombinant BRWD3 (1295-1443) protein gel.
BRWD3 (1295-1443) protein was run on a 10% SDS-PAGE gel and stained with Coomassie blue. |
