| 货号 | 31437 |
| 使用方法 | Recombinant SP140L (401-580) is suitable for use in binding assays, inhibitor screening, and selectivity profiling. |
| 供应商 | Active Motif |
| 背景 | SP140 nuclear body protein-like (SP140L) is a protein with significant sequence similarity to SP140, a component of the nuclear body that may be involved in trafficking between the nucleus and the cytoplasm. The protein is expressed as four isoforms produced by alternative splicing, SP140L contains one HSR domain, one PHD-type zinc finger, a bromodomain and one SAND domain. The bromodomain functions as a ‘reader’ of epigenetic histone marks and regulates chromatin structure and gene expression by linking associated proteins to the recognized acetylated nucleosomal targets. |
| 运输条件 | Dry Ice |
| 存放说明 | Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage. |
| 外观 | 100 µg of recombinant SP140L (401-580) protein expressed in E. coli at a concentration of 7.5 mg/ml in 25 mM HEPES pH 7.5, 150 mM NaCl and 5% glycerol. |
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Recombinant SP140L (401-580) protein gel. SP140L (401-580) protein was run on a 10% SDS-PAGE gel and stained with Coomassie blue. | |
Recombinant SP140L (401-580) activity using AlphaScreen. SP140L (401-580) was used in an AlphaScreen® assay to generate a titration curve demonstrating the signal response in the presence of modified peptide substrate at increasing protein concentrations. This data was generated and kindly provided courtesy of ChemPartner. |
