| 货号 | 31375 |
| 别名 | BR140, Peregrin |
| 使用方法 | Recombinant BRPF1 (627-746) is suitable for use in binding assays, inhibitor screening, and selectivity profiling. |
| 供应商 | Active Motif |
| 背景 | Bromodomain and PHD finger containing (BRPF1) protein is a component of the MOZ/MORF complex which has histone H3 acetyltransferase activity. The bromodomain of BRPF1 recognizes acetylated histone lysine residues and function as a ‘reader’ of these epigenetic histone marks to regulate chromatin structure and gene expression by linking associated proteins to the recognized acetylated nucleosomal targets. BRPF1 is known to positively regulate the transcription of RUNX1 and RUNX2. |
| 运输条件 | Dry Ice |
| 存放说明 | Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage. |
| 外观 | Recombinant BRPF1 (627-746) protein expressed in E. coli at a concentration of 10 mg/ml in 25 mM Tris pH 7.4, 150 mM NaCl and 5% glycerol. |
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Recombinant BRPF1 (627-746) protein gel. BRPF1 (627-746) protein was run on an SDS-PAGE gel and stained with Coomassie blue. | |
Recombinant BRPF1 (627-746) activity using AlphaScreen. BRPF1 (627-746) activity was assessed using an AlphaScreen® assay. Titration curves were generated to show signal response in the presence of modified peptide substrate at increasing protein concentrations.This data was generated and kindly provided courtesy of ChemPartner. |
