Recombinant PHIP (1302-1434) protein
货号：
31369 基本售价：
5872.5 元 规格：
100 ug
产品信息
概述| 货号 | 31369 |
| 别名 | ndrp; BRWD2; WDR11; DCAF14 |
| 使用方法 | Recombinant PHIP (1302-1434) is suitable for use in binding assays, inhibitor screening, and selectivity profiling. |
性能| 供应商 | Active Motif |
| 背景 | PH-interacting protein (PHIP), also known as WDR11orBRWD2, is a member of the WD repeat protein family. This family is characterized by regions of approximately 40 amino acids bracketed by gly-his and trp-asp (GH-WD), that potentially facilitate the formation of heterotrimeric or multimeric protein complexes. They also contain bromodomains that recognize acetylated histone lysine residues and function as ‘readers’ of these epigenetic histone marks to regulate chromatin structure and gene expression by linking associated proteins to the recognized acetylated nucleosomal targets. PHIP was isolated as a factor that binds to the pleckstrin homology (PH) domain of insulin receptor substrate-1 (IRS-1). PHIP was determined not to be a substrate of the insulin receptor but may instead regulate the insulin and insulin-like growth factor signaling pathways by linking IRS-1 to the insulin receptor. PHIP also stimulates cell proliferation through regulation of cyclin transcription and anti-apoptotic activity through AKT1 phosphorylation and activation. PHIP has also been shown to regulate cell morphology and cytoskeletal organization. In addition, PHIP has been implicated as a positive regulator of beta cell mitogenesis and survival. |
| 运输条件 | Dry Ice |
| 存放说明 | Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage. |
| 外观 | 100 µg of recombinant PHIP (1302-1434) protein expressed in E. coli at a concentration of 0.3 mg/ml in 25 mM HEPES pH 7.5, 150 mM NaCl and 5% glycerol. |
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参考图片Recombinant PHIP (1302-1434) protein gel.
PHIP (1302-1434) protein was run on a 10% SDS-PAGE gel and stained with Coomassie blue. |
