Recombinant TRIM33 (959-1069) protein
货号：
31367 基本售价：
5872.5 元 规格：
100 ug
产品信息
概述| 货号 | 31367 |
| 别名 | ECTO; PTC7; RFG7; TF1G; TIF1G; TIFGAMMA; TIF1GAMMA |
| 使用方法 | Recombinant TRIM33 (959-1069) is suitable for use in binding assays, inhibitor screening, and selectivity profiling. |
性能| 供应商 | Active Motif |
| 背景 | Tripartite motif-containing 33 (TRIM33) protein, also known as TIF1γ, is a member of the transcriptional intermediary factor 1 (TIF1) family that control transcription and chromatin remodeling through their interaction with transcription factors. The family includes TRIM24 (TIF1α), TRIM28 (TIF1β) and TRIM33 (TIF1γ) that share a characteristic domain structure comprised of multiple histone-binding domains, an N-terminal TRIM region (containing a RING domain, B box type 1 and type 2 domains, and a coiled-coil region), and a C-terminal bromodomain and PHD finger. Bromodomains function as ‘readers’ of epigenetic histone marks and regulate chromatin structure and gene expression by linking associated proteins to the recognized acetylated nucleosomal targets. TRIM33 is an E3 ubiquitin protein ligase that promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. TRIM33 does not affect SMAD4 levels but rather acts as an inhibitor of the SMAD4-dependent TGFβ/BMP signaling cascade by monoubiquitinating SMAD4 and hampering its ability to form a stable complex with activated SMAD2/3. TRIM33 may also act as a transcriptional corepressor. It has also been shown to associate with SMAD2 and SMAD3 and stimulate differentiation of hematopoietic stem cells. Additionally, TRIM33 associates with TRIM24 and plays a role in the control of cell proliferation. |
| 运输条件 | Dry Ice |
| 存放说明 | Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage. |
| 外观 | Recombinant TRIM33 (959-1069) protein expressed in E. coli at a concentration of 0.5 mg/ml in 25 mM HEPES pH 7.5, 150 mM NaCl and 5% glycerol. |
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参考图片Recombinant TRIM33 (959-1069) protein gel.
TRIM33 (959-1069) protein was run on an SDS-PAGE gel and stained with Coomassie blue. |
