Recombinant RXR-LBD protein
货号：
31365 基本售价：
5872.5 元 规格：
100 ug
产品信息
概述| 货号 | 31365 |
| 别名 | RAR, NR1B1 |
| 使用方法 | Recombinant RXR-LBD is suitable for in vitro transcription, ligand binding and protein-protein interaction assays. 20 ng is sufficient for in vitro transcription assays and 100 ng is sufficient for ligand binding and protein-protein interaction studies. |
性能| 供应商 | Active Motif |
| 背景 | TheRetinoid X receptor (RXR) ligand binding domain (LBD) is a promiscuous heterodimerization domain for binding of RXR to many nuclear receptors, including thyroid hormone receptors (TRs), retinoic acid receptors (RARs), peroxisome proliferator-activated receptor, orphan nuclear receptors and oxysterol receptors. Binding of RXR-LBD to nuclear receptors is mediated by the identity box, a 40-amino acid subregion within the ligand binding domain. The LBD is responsible for mediating transcription through receptor homo- and heterodimerization. The specific function of the RXR-containing complexes in regulating transcription depends on the associated ligand. For example, hormone binding to the LBD of the RXR results a conformational change that affects the C-terminal transactivation helix H12 involved in transcriptional activation. RXR-LBD ligand binding triggers dissociation of corepressor and the recruitment of coactivators, such as members of the Src family kinases, NCOA2/GRIP1, and RAC3/AIB1 which, in turn, promote transcription of downstream targets. |
| 运输条件 | Dry Ice |
| 存放说明 | Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage. |
| 外观 | 100 µg of recombinant RXR-LBD protein expressed in E. coli at a concentration of 5.49 mg/ml in 50 mM Tris pH 8.0, 150 mM NaCl, 1mM DTT and 50% glycerol. |
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参考图片RXR-LBD protein gel.
RXR-LBD run on an SDS-PAGE gel and stained with Coomassie blue. |
