| 货号 | 31353 |
| 别名 | Histone Deacetylase 8, HD8; WTS; RPD3; CDA07; CDLS5; HDACL1 |
| 使用方法 | Recombinant HDAC8 is suitable for use in histone deacetylase (HDAC) assays. It can also be used to study enzyme kinetics, inhibitor screening, and selectivity profiling. Specific Activity: 300 pmol/min/μg. |
| 供应商 | Active Motif |
| 背景 | HDAC8 (Histone Deacetylase 8) is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin. May play a role in smooth muscle cell contractility. |
| 运输条件 | Dry Ice |
| 存放说明 | Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage. |
| 外观 | 50 µg recombinant HDAC8 supplied at a concentration of 1.1 µg/µl in a buffer of 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 200 mM imidazole and 20% glycerol. |
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HDAC8 protein gel. HDAC8 run on an SDS-PAGE gel and stained with Coomassie blue. | |
HDA8 activity assay. Recombinant HDAC8 activity measured using a fluorescent HDAC assay. |
