Recombinant SIRT5 protein
货号：
31531 基本售价：
5872.5 元 规格：
100 ug
产品信息
概述| 货号 | 31531 |
| 别名 | SIRT-5, Sirtuin 5, SIR2L5, SIR2-Like Protein 5 |
| 使用方法 | Recombinant SIRT5 protein is useful for protein deacetylase, demalonylase, desuccinylase and deglutarylase assays and the study of enzyme kinetics, screening inhibitors, and selectivity profiling. |
性能| 供应商 | Active Motif |
| 背景 | SIRT5 (Sirtuin 5) is a member of the SIR2 / Sirtuin family of NAD+-dependant deacetylase enzymes. Sirtuin family enzymes can be found in the cytoplasm, mitochondria or nucleus of a cell and are ubiquitously expressed. SIRT5 has multiple enzymatic functions, such as NAD+-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. SIRT5 catalyzes more efficiently removal of malonyl- and succinyl- and glutaryl- than acetyl-lysine modifications. SIRT5 activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting by mediating desuccinylation and deglutarylation of CPS1. SIRT5 also activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. It can modulate ketogenesis through the desuccinylation and activation of HMGCS2. SIRT5 can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as UOX. |
| 运输条件 | Dry Ice |
| 存放说明 | Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage. |
| 外观 | Full length recombinant SIRT5 protein is supplied in 25 mM Tris pH 8.0, 150 mM NaCl, 5% glycerol. Please refer to product insert upon arrival for lot-specific concentration. |
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