Recombinant HDAC9 (604-1066) protein
货号：
31537 基本售价：
5872.5 元 规格：
20 ug
产品信息
概述| 货号 | 31537 |
| 别名 | Histone Deacetylase 9, HDAC-9, Histone Deacetylase 7B, HDAC7B, HD9 |
| 使用方法 | Recombinant HDAC9 (604-1066) protein is useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiing. |
性能| 供应商 | Active Motif |
| 背景 | HDAC9 (Histone Deacetylase 9) is a member of the class IIa mammalian histone deacetylases (HDACs) involved in regulating chromatin structure during transcription. These enzymes catalyze the removal of acetyl groups from lysine residues of histones and other cellular proteins. Lysine N-ε-acetylation is a dynamic, reversible and tightly regulated protein and histone modification that plays a major role in regulation of gene expression in various cellular functions. It consists of the transfer of an acetyl moiety from an acetyl coenzyme A to the ε-amino group of a lysine residue.
In vivo, acetylation is controlled by the antagonistic activities of histone acetyltransferases (HATs) and histone deacetylases (HDACs). The HDACs are grouped into four classes, on the basis of similarity to yeast counterparts: HDAC class I (HDAC1, HDAC2, HDAC3 and HDAC8), class II (HDAC4, HDAC5, HDAC6, HDAC7, 9 and 10), class III (SIRT1-7) and class IV (HDAC11).
In humans, HDAC9 is expressed in a wide variety of tissues. This gene is orthologous to the Xenopus and mouse MITR genes. HDAC9 represses MEF2 activity through recruitment of multicomponent corepressor complexes that include CtBP and HDAC1 and/or HDAC3. HDAC9 may play a role in hematopoiesis. It seems to inhibit skeletal myogenesis and to be involved in heart development. HDAC9 protects neurons from apoptosis, both by inhibiting JUN phosphorylation by MAPK10 and by repressing JUN transcription via HDAC1 recruitment to JUN promoter. |
| 运输条件 | Dry Ice |
| 存放说明 | Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage. |
| 外观 | Recombinant HDAC9 (604-1066) protein is supplied in 25 mM HEPES pH 7.5, 300 mM NaCl, 5% Glycerol, 0.04% Triton X-100, 0.2 mM TCEP. Please refer to product insert upon arrival for lot-specific concentration. |
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