| 货号 | 10004174-1mg |
| 描述 | 4-oxo-2-Nonenal-d3(4-ONE-d3) contains three deuterium atoms at the terminal methyl position. It is intended for use as an internal standard for the quantification of 4-ONE (Item No. 10185) by GC- or LC-mass spectrometry (MS). 4-ONE is a lipid peroxidation product derived from oxidized ω-6 polyunsaturated fatty acids such as arachidonic acid and linoleic acid.1,2 It exhibits various biological activities such as cytotoxicity, growth inhibiting activity, genotoxicity, and chemotactic activity and has been widely used as a marker of lipid peroxidation.1,2,3 4-ONE is a more recently identified product of lipid peroxidation.4,5,6 It actively modifies histidine and lysine residues on proteins and causes protein cross-linking.7,8 4-ONE also modifies 2-deoxy guanosine, further implicating lipid peroxidation in mutagenesis and carcinogenesis.1 |
| 别名 | 4-ONE-d3; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Pryor, W.A., and Porter, N.A. Suggested mechanisms for the production of 4-hydroxy-2-nonenal from the autoxidation of polyunsaturated fatty acids. Free Radical Biology & Medicine 8, 541-543 (1990). 2.Esterbauer, H.,Schaur, R.J., and Zoliner, H. Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde, and related aldehydes. Free Radical Biology & Medicine 11, 81-128 (1991). 3.Sodum, R.S., and Chung, F.L. 1,N2-ethenodeoxyguanosine as a potential marker for DNA adduct formation by trans-4-hydroxy-2-nonenal. Cancer Research 48, 320-323 (1988). 4.Rindgen, D.,Nakajima, M.,Wehrli, S., et al. Covalent modifications to 2-deoxyguanosine by 4-oxo-nonenal, a novel product of lipid peroxidation. Chemical Research in Toxicology 12, 1195-1204 (1999). 5.Lee, S.H., and Blair, I.A. Characterization of 4-oxo-2-nonenal as a novel product of lipid peroxidation. Chemical Research in Toxicology 13, 698-702 (2000). 6.Spiteller, P.,Kern, W.,Reiner, J., et al. Aldehydic lipid peroxidation products derived from linoleic acid. Biochimica et Biophysica Acta 1531, 188-208 (2001). 7.Liu, Z.,Minkler, P.E., and Sayre, L.M. Mass spectroscopic characterization of protein modification by 4-hydroxy-2-(E)-nonenal and 4-oxo-2-(E)-nonenal. Chemical Research in Toxicology 16, 901-911 (2003). 8.Zhang, W.H.,Liu, J.,Xu, G., et al. Model studies on protein side chain modification by 4-oxo-2-nonenal. Chemical Research in Toxicology 16, 512-523 (2003). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 纯度 | ≥99% deuterated forms (d1-d3) |
| 计算分子量 | 157.2 |
| 分子式 | C9H11D3O2 |
| CAS号 | 1313400-91-7 |
| 稳定性 | ≥ 6 months |
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