CAY10441
货号：
10005186-25mg 基本售价：
12502.0 元 规格：
25 mg
产品信息
概述| 货号 | 10005186-25mg |
| 描述 | Recently, a series of relatively simple compounds were found to be high-affinity ligands and functional antagonists for the human IP (prostacyclin) receptor.1 CAY10441 is one of the more potent of these. CAY10441 antagonizes the carbaprostacyclin-induced activation of human neuroblastoma adenylate cyclase, blocking cyclic AMP accumulation in a dose-dependent manner. Likewise, it inhibits the binding of tritiated iloprost to rodent neuroblastoma cells with a Ki of about 1.5 nM. At levels between 2-20 mg/kg in rats, CAY10441 shows significant analgesic activity in standard antinociceptive assays.1 |
| 别名 | RO1138452; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Clark, R.D.,Jahangir, A.,Severance, D., et al. Discovery and SAR development of 2-(phenylamino) imidazolines as prostacyclin receptor antagonists. Bioorganic & Medicinal Chemistry Letters 14, 1053-1056 (2004).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 309.4 |
| 分子式 | C19H23N3O |
| CAS号 | 221529-58-4 |
| 稳定性 | ≥ 2 years |
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