Thromboxane B1
货号：
10006610-10mg 基本售价：
12320.0 元 规格：
10 mg
产品信息
概述| 货号 | 10006610-10mg |
| 描述 | Dihomo-g-linolenic acid (DGLA) is one of the 20-carbon fatty acids that can be metabolized to prostaglandins and thromboxanes (TXs) by cyclooxygenases 1 and 2 (COX-1/COX-2).1 The result of this metabolism in the human platelet yields TXB1. TXB1 is produced in small amounts when DGLA is added to washed suspensions of human platelets, while the major metabolism of this 1-series fatty acid is via12-lipoxygenase.2 However, when co-incubated with amounts of ethanol often found in intoxicated humans, the metabolism of DGLA shifts to an enhanced production of TXB1.2 Urinary TXB1 or its metabolites may thus be a specific biomarker of prior ethanol abuse. |
性能| 供应商 | Cayman |
| 应用文献 |
1.Levin, G.,Duffin, K.L.,Obukowicz, M.G., et al. Differential metabolism of dihomo-γ-linolenic acid and arachidonic acid by cyclo-oxygenase-1 and cyclo-oxygenase-2: Implications for cellular synthesis of prostaglandin E1 and prostaglandin E2. Biochemistry Journal 365, 489-496 (2002).
2.Manku, M.S.,Oka, M., and Horrobin, D.F. Differential regulation of the formation of prostaglandins and related substances from arachidonic acid and from dihomogammalinolenic acid. I. Effects of ethanol. Prostaglandins and Medicine 3(2), 119-128 (1979).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | >98% |
| 计算分子量 | 372.5 |
| 分子式 | C20H36O6 |
| CAS号 | 64626-32-0 |
| 稳定性 | ≥ 2 years |
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