| 货号 | 10005707-10mg |
| 描述 | Lysophosphatidic acid (LPA) is a potent lipid mediator that elicits its effect through four distinct receptors - LPA1/EDG-2, LPA2/EDG-4, LPA3/EDG-7 and LPA4/GPR23.1,2 OMPT is a selective agonist of the lysophosphatidic acid 3 (LPA3) receptor. It exhibits EC50 values of 68 nM and >6.8 µM for calcium mobilization in LPA1 and LPA2-expressing Sf9 cells, respectively.3 The (2S)-OMPT enantiomer is 5- to 20-fold more active than (2R)-OMPT in calcium release assays in both LPA3-transfected Sf9 and rat hepatoma Rh7777 cells.4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Chun, J.,Goetzl, E.J.,Hla, T., et al. International union of pharmacology. XXXIV. Lysophospholipid receptor nomenclature. Pharmacological Reviews 54, 265-269 (2002). 2.Niu, S.L.,Mitchell, D.C., and Litman, B.J. Trans fatty acid derived phospholipids show increased membrane cholesterol and reduced receptor activation as compared to their cis analogs. Biochemistry 44, 4458-4465 (2005). 3.Hasegawa, Y.,Erickson, J.R.,Goddard, G.J., et al. Identification of a phosphothionate analogue of lysophosphatidic acid (LPA) as a selective agonist of the LPA3 receptor. The Journal of Biological Chemisty 278(14), 11962-11969 (2003). 4.Qian, L.,Xu, Y.,Hasegawa, Y., et al. Enantioselective responses to a phosphorothioate analogue of lysophosphatidic acid with LPA3 receptor-selective agonist activity. Journal of Medicinal Chemistry 46, 5575-5578 (2003). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 669 |
| 分子式 | C22H43O6PS • 2(C2H5)3N |
| CAS号 | 1217471-69-6 |
| 稳定性 | ≥ 1 year |
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