Araguspongin B
货号：
10006797-250ug 基本售价：
10878.0 元 规格：
250 ug
产品信息
概述| 货号 | 10006797-250ug |
| 描述 | Xestospongins and araguspongins are marine natural products first isolated from Pacific basin sponges, and noted to have vasodilatory properties.1 Inositol phosphates (IP) are important signal transduction messengers acting viaIP3 receptors to promote the mobilization of Ca2+ from intracellular stores.2 Araguspongin B antagonizes the calcium-releasing action of inositol 1,4,5-trisphosphate at the receptor level in cerebral microsomes, with an IC50 of 0.6 µM.3 It is nearly as potent as xestospongin C as an antagonist of the IP3receptor. |
性能| 供应商 | Cayman |
| 应用文献 |
1.Nakagawa, M., and Endo, M. Structures of xestospongin A, B, C and D, novel vasodilative compounds from marine sponge, Xestospongia exigua. Tetrahedron Letters 25(30), 3227-3230 (1984).
2.Majerus, P.W. Inositol phosphate biochemistry. Annual Reviews of Biochemistry 61, 225-250 (1992).
3.Gafni, J.,Munsch, J.A.,Lam, T.H., et al. Xestospongins: Potent membrane permeable blockers of the inositol 1,4,5-triphosphate receptor. Neuron 19, 723-733 (1997).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥90% |
| 计算分子量 | 446.7 |
| 分子式 | C28H50N2O2 |
| CAS号 | 123000-02-2 |
| 稳定性 | ≥ 1 year |
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