| 货号 | 10006305-50mg |
| 描述 | Ceramidase acts in normal cells to keep ceramide concentrations low and maintain cell viability. The inhibition of ceramidase in both malignant and non-cancerous cells leads to apoptosis.1,2 D-NMAPPD is a potent ceramidase inhibitor that induces apoptosis in human colorectal cancer, keratinocyte, and melanoma cell lines.3,4 D-NMAPPD produces approximately 50% cell non-viability at 10 µM and >80% cell death at 100 µM.4 |
| 别名 | (1R,2R)-B13;CAY10466; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Geley, S.,Hartmann, B.L., and Kofler, R. Ceramides induce a form of apoptosis in human acute lymphoblastic leukemia cells that is inhibited by Bcl-2, but not by CrmA. FEBS Letters 400, 15-18 (1997). 2.Kolesnick, R. The therapeutic potential of modulating the ceramide/sphingomyelin pathway. Journal of Clinical Investigation 110(1), 3-8 (2002). 3.Raisova, M.,Goltz, G.,Bektas, M., et al. Bcl-2 overexpression prevents apoptosis induced by ceramidase inhibitors in malignant melanoma and HaCaT keratinocytes. FEBS Letters 516, 47-52 (2002). 4.Selzner, M.,Bielawska, A.,Morse, M.A., et al. Induction of apoptotic cell death and prevention of tumor growth by ceramide analogues in metastatic human colon cancer. Cancer Research 61, 1233-1240 (2001). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 422.6 |
| 分子式 | C23H38N2O5 |
| CAS号 | 35922-06-6 |
| 稳定性 | ≥ 2 years |
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