| 货号 | 10004413-10mg |
| 描述 | 4-hydroxy Nonenal (4-HNE; Item No. 32100) is a lipid peroxidation product derived from oxidized ω-6 polyunsaturated fatty acids, such as linoleic acid and arachidonic acid, that is widely used as a marker of oxidative stress.1,2 4-HNE exhibits various biological activities such as cytotoxicity, growth inhibiting activity, genotoxicity, and chemotactic activity.1,2,3 4-hydroperoxy 2-Nonenal is the immediate precursor of 4-HNE formed from the cleavage of ω-6 hydroperoxides.4 Analogous reactions are expected to occur with hydroperoxides from other ω-6 fatty acids, particularly arachidonic acid. |
| 别名 | 4-HpNE; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Pryor, W.A., and Porter, N.A. Suggested mechanisms for the production of 4-hydroxy-2-nonenal from the autoxidation of polyunsaturated fatty acids. Free Radical Biology & Medicine 8, 541-543 (1990). 2.Esterbauer, H.,Schaur, R.J., and Zoliner, H. Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde, and related aldehydes. Free Radical Biology & Medicine 11, 81-128 (1991). 3.Sodum, R.S., and Chung, F.L. 1,N2-ethenodeoxyguanosine as a potential marker for DNA adduct formation by trans-4-hydroxy-2-nonenal. Cancer Research 48, 320-323 (1988). 4.Schneider, C.,Tallman, K.A.,Porter, N.A., et al. Two distinct pathways of formation of 4-hydroxynonenal. Mechanisms of nonenzymatic transformation of the 9- and 13-hydroperoxides of linoleic acid to 4-hydroxyalkenals. The Journal of Biological Chemisty 276(24), 20831-20838 (2001). | |
| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 纯度 | ≥95% |
| 计算分子量 | 172.2 |
| 分子式 | C9H16O3 |
| CAS号 | 7439-43-2 |
| 稳定性 | ≥ 1 year |
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