| 货号 | 10004219-50mg |
| 描述 | The physiologic roles and importance of constitutive COX-1 and inducible COX-2 have been reviewed.1,2 SC-236 is a potent, selective, orally active inhibitor of COX-2 with an IC50 of 10 nM and approximately 18,000-fold COX-2 selectivity.3 SC-236 has a long plasma half-life and can be dosed once daily (20 mg/kg) in rodents to achieve lasting inhibition of COX-2.4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Fitzpatrick, F.A., and Soberman, R. Regulated formation of eicosanoids. Journal of Clinical Investigation 107(11), 1339-1345 (2001). 2.Bertolini, A.,Ottani, A., and Sandrini, M. Selective COX-2 inhibitors and dual acting anti-inflammatory drugs: Critical remarks. Current Medicinal Chemistry 9, 1033-1043 (2002). 3.Penning, T.D.,Talley, J.J.,Bertenshaw, S.R., et al. Synthesis and biological evaluation fo the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: Identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide (SC-58635, celecoxib). Journal of Medicinal Chemistry 40, 1347-1365 (1997). 4.Loftin, C.D.,Trivedi, D.B., and Langenbach, R. Cyclooxygenase-1-selective inhibition prolongs gestation in mice without adverse effects on the ductus arteriosus. Journal of Clinical Investigation 110(4), 549-557 (2002). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 401.8 |
| 分子式 | C16H11ClF3N3O2S |
| CAS号 | 170569-86-5 |
| 稳定性 | ≥ 2 years |
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