Y-27632 (hydrochloride)
货号：
10005583-50mg 基本售价：
7560.0 元 规格：
50 mg
产品信息
概述| 货号 | 10005583-50mg |
| 描述 | The ROCK family of Rho-associated serine-threonine protein kinases is known to play an important role in Rho-mediated cell adhesion and smooth muscle contraction. Y-27632 is a potent, ATP-competitive inhibitor of ROCKs including p160ROCK (Ki = 140 nM) and ROCK-II (IC50 = 800 nM). It also inhibits PRK2 with an IC50 value of 600 nM.1,2 One-hour treatment with 10 µM Y-27632 blocks apoptosis of dissociated cultured human embryonic stem cells, increasing cloning efficiency by 25% and sustaining survival up to 30 passages.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Davies, S.P.,Reddy, H.,Caivano, M., et al. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochemistry Journal 351, 95-105 (2000).
2.Uehata, M.,Ishizaki, T.,Satoh, H., et al. Calcium sensitization of smooth muscle mediated by a Rho-assocciated protein kinase in hypertension. Nature 389, 990-994 (1997).
3.Watanabe, K.,Ueno, M.,Kamiya, D., et al. A ROCK inhibitor permits survival of dissociated human embryonic stem cells. Nature Biotechnology 25(6), 681-686 (2007).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 320.3 |
| 分子式 | C14H21N3O • 2HCl |
| CAS号 | 129830-38-2 |
| 稳定性 | ≥ 2 years |
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