Cerulenin
货号：
10005647-50mg 基本售价：
7280.0 元 规格：
50 mg
产品信息
概述| 货号 | 10005647-50mg |
| 描述 | A number of tumor cells and cell lines have been observed to have highly upregulated expression and activity of fatty acid synthase (FAS). Inhibition of FAS by the irreversible inhibitor cerulenin leads to cytotoxicity and apoptosis in human cancer cell lines,1 an effect believed to be mediated by the accumulation of malonyl-coenzyme A in cells with an upregulated FAS pathway.2 Cerulenin also leads to profound weight loss and feeding inhibition in both high-fat diet wild type obese and leptin-deficient ob/obmice.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Moche, M.,Schneider, G.,Edwards, P., et al. Structure of the complex between the antibiotic cerulenin and its target, β-ketoacyl-acyl carrier protein synthase. The Journal of Biological Chemisty 274(10), 6031-6034 (1999).
2.Pizer, E.S.,Thupari, J.,Han, W.F., et al. Malonyl-coenzyme-A is a potential mediator of cytotoxicity induced by fatty-acid synthase inhibition in human breast cancer cells and xenografts. Cancer Research 60, 213-218 (2000).
3.Loftus, T.M.,Jaworsky, D.E.,Frehywot, G.L., et al. Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors. Science 288, 2379-2381 (2000).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 223.3 |
| 分子式 | C12H17NO3 |
| CAS号 | 17397-89-6 |
| 稳定性 | ≥ 2 years |
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