| 货号 | 10006556-1mg |
| 描述 | Latanoprost-d4 contains four deuterium atoms at the 3, 3, 4, and 4 positions. It is intended for use as an internal standard for the quantification of latanoprost by GC- or LC-mass spectrometry. Latanoprost is the isopropyl ester of 17-phenyl-13,14-dihydro prostaglandin F2α. It is a prodrug form of the free acid, which is a potent agonist of the FP receptor in the eye. Latanoprost reduces intraocular pressure in glaucoma patients with few side effects.1,2,3 The EC50 value of latanoprost for (free acid) for FP receptors is 3.6 nM.4 |
| 别名 | 17-phenyl-13,14-dihydro trinor Prostaglandin F2α-d4 isopropyl ester; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Lindén, C.,Nuija, E., and Alm, A. Effects on IOP restoration and blood-aqueous barrier after long term treatment with latanoprost in open angle glaucoma and ocular hypertension. British Journal of Ophthalmology 81, 370-372 (1997). 2.Camras, C.B.,Alm, A.,Watson, P., et al. Latanoprost, a prostaglandin analog, for glaucoma therapy. Efficacy and safety after 1 year of treatment in 198 patients. Ophthalmology 103, 1916-1924 (1996). 3.Alm, A.,Villumsen, J.,Törnquist, P., et al. Intraocular pressure-reducing effect of PhXA41 in patients with increased eye pressure. A one-month study. Ophthalmology 100, 1312-1317 (1993). 4.Stjernschantz, J., and Resul, B. Phenyl substituted prostaglandin analogs for glaucoma treatment. Drugs of the Future 17, 691-704 (1992). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥99% deuterated forms (d1-d4) |
| 计算分子量 | 436.6 |
| 分子式 | C26H36D4O5 |
| 稳定性 | ≥ 2 years |
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