Valdecoxib
货号：
10006120-50mg 基本售价：
6496.0 元 规格：
50 mg
产品信息
概述| 货号 | 10006120-50mg |
| 描述 | Valdecoxib is a non-steroidal anti-inflammatory drug that selectively inhibits COX-2, exhibiting IC50 values of 26.1 and 0.87 µM for COX-1 and COX-2, respectively, in a human whole blood assay.1 The COX-2 selectivity ratio of 30 for valdecoxib in this assay is similar to the ratio of 35 observed for rofecoxib (Item No. 10010260).1 COX-2 selective inhibitors, including this compound, have been implicated as risk factors in acute atherothrombotic events.2,3 |
| 别名 | Bextra; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Mardini, I.A., and Fitzgerald, G.A. Selective inhibitors of cyclooxygenase-2: A growing class of anti-inflammatory drugs. Molecular Interventions 1(1), 30-38 (2001).
2.Walter, M.F.,Jacob, R.F.,Day, C.A., et al. Sulfone COX-2 inhibitors increase susceptibility of human LDL and plasma to oxidative modification: Comparison to sulfonamide COX-2 inhibitors and NSAIDs. Atherosclerosis 177, 235-243 (2004).
3.Zhang, J.,Ding, E.L., and Song, Y. Adverse effects of cyclooxygenase 2 inhibitors on renal and arrhythmia events: Meta-analysis of randomized trials. Journal of the American Medical Association 296(13), 1619-1632 (2006).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 314.4 |
| 分子式 | C16H14N2O3S |
| CAS号 | 181695-72-7 |
| 稳定性 | ≥ 2 years |
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