12(R)-HETE
货号：
34560-100ug 基本售价：
6048.0 元 规格：
100 ug
产品信息
概述| 货号 | 34560-100ug |
| 描述 | Biosynthesis of 12(R)-HETE in invertebrates is via lipoxygenation of arachidonic acid (Item No. 90010).1 In mammals, 12(R)-HETE can be produced by 12(R)-LOs and also by CYP450 oxidation.2,3 The activity of 12(R)-HETE in mammals is predominantly proinflammatory.2 12(R)-HETE exhibits dose-dependent leukocyte chemotaxis at concentrations as low as 100 nM, and lowers intraocular pressure in rabbits. |
性能| 供应商 | Cayman |
| 应用文献 |
1.Hawkins, D.J., and Brash, A.R. Eggs of the sea urchin, Strongylocentrotus purpuratus, contain a prominent (11R) and (12R) lipoxygenase activity. The Journal of Biological Chemisty 262, 7629-7634 (1987).
2.Schwartzman, M.L.,Balazy, M.,Masferrer, J., et al. 12(R)-Hydroxyeicosatetraenoic acid: A cytochrome P450-dependent arachidonate metabolite that inhibits Na+,K+-ATPase in the cornea. Proceedings of the National Academy of Sciences of the United States of America 84, 8125-8129 (1987).
3.Capdevila, J.,Yadagiri, P.,Manna, S., et al. Absolute configuration of the hydroxyeicosatetraenoic acids (HETEs) formed during catalytic oxygenation of arachidonic acid by microsomal cytochrome P-450. Biochemical and Biophysical Research Communications 141, 1007-1011 (1986).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 320.5 |
| 分子式 | C20H32O3 |
| CAS号 | 82337-46-0 |
| 稳定性 | ≥ 1 year |
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