| 货号 | 34505-100ug |
| 描述 | 11(R)-HETE is biosynthesized by 11(R)-LOs of the sea urchin, S. purpuratus, and the fresh water hydra, H. vulgaris.1,2 The biological activity of 11(R)-HETE relates to oocyte maturation and tentacle regeneration, respectively, in these two species. 11(R)-HETE is also produced when aspirin-treated recombinant COX-2 is incubated with arachidonic acid.3 Stereochemical assignment of the (R) enantiomer is based on comparison of chiral HPLC retention times to published results. 4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Hawkins, D.J., and Brash, A.R. Eggs of the sea urchin, Strongylocentrotus purpuratus, contain a prominent (11R) and (12R) lipoxygenase activity. The Journal of Biological Chemisty 262, 7629-7634 (1987). 2.Di Marzo, V.,Gianfrani, C.,De Petrocellis, L., et al. Polyunsaturated-fatty-acid oxidation in Hydra: Regioselectivity, substrate-dependent enantioselectivity and possible biological role. Biochemistry Journal 300, 501-507 (1994). 3.Xiao, G.,Tsai, A.l.,Palmer, G., et al. Analysis of hydroperoxide-induced tyrosyl radicals and lipoxygenase activity in aspirin-treated human prostaglandin H synthase-2. Biochemistry 36, 1836-1845 (1997). 4.Schneider, C.,Yu, Z.,Boeglin, W.E., et al. Enantiomeric separation of hydroxy and hydroperoxy eicosanoids by chiral column chromatography. Method.Enzymol. 433, 145-157 (2015). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 320.5 |
| 分子式 | C20H32O3 |
| CAS号 | 73347-43-0 |
| 稳定性 | ≥ 1 year |
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