(±)18-HETE
货号：
10010638-100ug 基本售价：
6048.0 元 规格：
100 ug
产品信息
概述| 货号 | 10010638-100ug |
| 描述 | (±)18-HETE is the racemic version of a cytochrome P450 (CYP450) metabolite of arachidonic acid. When formed by the CYP2E1 isoform, 18-HETE is comprised 100% of the (R) isomer.1 18(R)-HETE dose-dependently stimulates vasodilation of the rabbit kidney, whereas 18(S)-HETE does not affect perfusion pressure.2 18-HETE has negligible effects on ATPase activity.2 18(R)-HETE at 1 µM completely blocks 20-HETE-induced vasoconstriction of renal arterioles.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Laethem, R.M.,Balazy, M.,Falck, J.R., et al. Formation of 19(S)-, 19(R)-, and 18(R)-hydroxyeicosatetraenoic acids by alcohol-inducible cytochrome P450 2E1. The Journal of Biological Chemisty 268(17), 12912-12918 (1993).
2.Carroll, M.A.,Balazy, M.,Margiotta, P., et al. Cytochrome P-450-dependent HETEs: Profile of biological activity and stimulation by vasoactive peptides. American Journal of Physiology 271, R863-R869 (1996).
3.Zhang, F.,Deng, H.,Kemp, R., et al. Decreased levels of cytochrome P450 2E1-derived eicosanoids sensitize renal arteries to constrictor agonists in spontaneously hypertensive rats. Hypertension 45, 103-108 (2005).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥97% |
| 计算分子量 | 320.5 |
| 分子式 | C20H32O3 |
| CAS号 | 133268-58-3 |
| 稳定性 | ≥ 1 year |
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