| 货号 | 10007767-100ug |
| 描述 | 19-HETE is one of the major cytochrome P450 (CYP450) metabolites of arachidonic acid that is released from the kidney in response to angiotensin II. When formed by the CYP2E1 isoform, 19-HETE is composed of 70% and 30% of the (S) and (R) stereoisomers, respectively.1 Both 19(S)- and 19(R)-HETE are potent vasodilators of renal preglomerular vessels.2 However, 19(R)-HETE at 1 µM completely blocks 20-HETE-induced vasoconstriction of renal arterioles, whereas 19(S)-HETE remains inactive.3,4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Laethem, R.M.,Balazy, M.,Falck, J.R., et al. Formation of 19(S)-, 19(R)-, and 18(R)-hydroxyeicosatetraenoic acids by alcohol-inducible cytochrome P450 2E1. The Journal of Biological Chemisty 268(17), 12912-12918 (1993). 2.Carroll, M.A.,Balazy, M.,Margiotta, P., et al. Cytochrome P-450-dependent HETEs: Profile of biological activity and stimulation by vasoactive peptides. American Journal of Physiology 271, R863-R869 (1996). 3.Alonso-Galicia, M.,Falck, J.R.,Reddy, K.M., et al. 20-HETE agonists and antagonists in the renal circulation. American Journal of Physiology.Renal Physiology 277, 790-796 (1999). 4.Zhang, F.,Deng, H.,Kemp, R., et al. Decreased levels of cytochrome P450 2E1-derived eicosanoids sensitize renal arteries to constrictor agonists in spontaneously hypertensive rats. Hypertension 45, 103-108 (2005). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 320.5 |
| 分子式 | C20H32O3 |
| CAS号 | 115461-39-7 |
| 稳定性 | ≥ 1 year |
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