TOFA
货号：
10005263-100mg 基本售价：
5684.0 元 规格：
100 mg
产品信息
概述| 货号 | 10005263-100mg |
| 描述 | Inhibition of fatty acid synthase (FAS) by the irreversible inhibitor cerulenin leads to cytotoxicity and apoptosis in human cancer cell lines.1 TOFA is an inhibitor of fatty acid synthesis blocking the synthesis of malonyl-CoA by acetyl-CoA carboxylase (ACC).2 Both cerulenin (at about 10 µg/ml) and TOFA (at about 1 µg/ml) are effective at blocking the incorporation of radiolabeled acetate into palmitate. However, TOFA reduces malonyl-CoA levels rather than elevating them, and TOFA is relatively non-toxic to various cancer cell lines. TOFA also attenuates the inhibition of feeding observed when FAS inhibitors such as cerulenin and C75 are administered to obese ob/obmice. |
| 别名 | RMI 14514;5-(Tetradecyloxy)-2-furoic Acid; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Moche, M.,Schneider, G.,Edwards, P., et al. Structure of the complex between the antibiotic cerulenin and its target, β-ketoacyl-acyl carrier protein synthase. The Journal of Biological Chemisty 274(10), 6031-6034 (1999).
2.Loftus, T.M.,Jaworsky, D.E.,Frehywot, G.L., et al. Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors. Science 288, 2379-2381 (2000).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 324.5 |
| 分子式 | C19H32O4 |
| CAS号 | 54857-86-2 |
| 稳定性 | ≥ 2 years |
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