| 货号 | 10008128-100ug |
| 描述 | Protectin D1 (also known as neuroprotectin D1 when produced in neuronal tissues) is a DHA-derived dihydroxy fatty acid that exhibits potent protective and anti-inflammatory activities.1,2,3 10(S),17(S)-DiHDHA is a DHA metabolite, also referred to as protectin DX (PDX).4 It is produced by an apparent double lipoxygenase (LO)-mediated reaction in murine peritonitis exudates, in suspensions of human leukocytes, or by soybean 15-LO incubated with DHA.1,4 It differs from protectin D1 with respect to the stereochemistry of the C-10 hydroxyl and the double bond configuration at the 13 and 15 positions. 10(S),17(S)-DiHDHA blocks neutrophil infiltration in murine peritonitis by 20-25% at a dose of 1 ng/mouse.1 It also inhibits platelet activation by both impairing thromboxane (TX) synthesis and TX receptor activation.4,5 |
| 别名 | 10(S),17(S)-DiHDoHE;PDX;Protectin DX; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Serhan, C.N.,Gotlinger, K.,Hong, S., et al. Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its natural stereoisomers: Assignments of dihydroxy-containing docosatrienes. Journal of Immunology 176, 1848-1859 (2006). 2.Ariel, A., and Serhan, C.N. Resolvins and protectins in the termination program of acute inflammation. TRENDS in Immunology 28(4), 176-183 (2007). 3.Schwab, J.M.,Chiang, N.,Arita, M., et al. Resolvin E1 and protectin D1 activate inflammation-resolution programmes. Nature 447, 869-875 (2007). 4.Chen, P.,Fenet, B.,Michaud, S., et al. Full characterization of PDX, a neuroprotectin/protectin D1 isomer, which inhibits blood platelet aggregation. FEBS Letters 583, 3478-3484 (2009). 5.Chen, P.,Véricel, E.,Lagarde, M., et al. Poxytrins, a class of oxygenated products from polyunsaturated fatty acids, potently inhibit blood platelet aggregation. The FASEB Journal 25, 382-388 (2011). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 360.5 |
| 分子式 | C22H32O4 |
| CAS号 | 871826-47-0 |
| 稳定性 | ≥ 1 year |
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