| 货号 | 10009832-500ug |
| 描述 | (±)12(13)-DiHOME is the diol resulting from the soluble epoxide hydrolase opening of (±)12(13)-EpOME (Item No. 52450). The mixture of the methyl ester of this diol and the 9,10 isomer are more cytotoxic than the methyl ester epoxides in renal proximal tubular cells.1 However, in renal cortical mitochondria, the conversion of the epoxide to (±)12(13)-DiHOME appears to be part of the detoxification pathway that prevents mitochondrial dysfunction.2 This diol and the 9,10 isomer can be glucuronidated by human liver and intestinal microsomes as well as recombinant UGT2B7 through a hydroxyl group. High levels of LA-diol glucuronides have been found in the urine of humans with peroxisomal diseases.3 A mixture of the diols stimulates breast cancer cell proliferation in vitro and disrupts reproductive function in rats at relatively low concentrations.4 |
| 别名 | Isoleukotoxin diol; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Moran, J.H.,Weise, R.,Schnellmann, R.G., et al. Cytotoxicity of linoleic acid diols to renal proximal tubular cells. Toxicology and Applied Pharmacology 146, 53-59 (1997). 2.Moran, J.H.,Nowak, G., and Grant, D.F. Analysis of the toxic effects of linoleic acid, 12,13-cis-epoxyoctadecenoic acid, and 12,13-dihydroxyoctadecenoic acid in rabbit renal cortical mitochondria. Toxicology and Applied Pharmacology 172, 150-161 (2001). 3.Jude, A.R.,Little, J.M.,Czernik, P.J., et al. Glucuronidation of linoleic acid diols by human microsomal and recombinant UDP-glucuronosyltransferases: Identification of UGT2B7 as the major isoform involved. Archives of Biochemistry and Biophysics 389(2), 176-186 (2001). 4.Markaverich, B.M.,Crowley, J.R.,Alejandro, M.A., et al. Leukotoxin diols from ground corncob bedding disrupt estrous cyclicity in rats and stimulate MCF-7 breast cancer cell proliferation. Environmental Health Perspectives 113(12), 1698-1704 (2005). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 314.5 |
| 分子式 | C18H34O4 |
| CAS号 | 263399-35-5 |
| 稳定性 | ≥ 1 year |
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