Caylin-1
货号：
10004985-10mg 基本售价：
5600.0 元 规格：
10 mg
产品信息
概述| 货号 | 10004985-10mg |
| 描述 | Nutlin-3 is an activator of p53 that functions by inhibiting the interaction of p53 with MDM2, a negative regulator of p53 activity.1 Caylin-1 is a nutlin-3 analog which contains chlorine substituents at the 3 and 4 positions on two of the phenyl rings rather than a single 4-chloro as seen in nutlin-3. At high concentrations, caylin-1 inhibits the growth of HCT116 cells with an IC50 value of approximately 7 µM, making it about 7-fold less potent than nutlin-3 in the same assay. Interestingly, at concentrations at or below 1 µM, caylin-1 promotes the growth of HCT116 cells approximately 20% compared to untreated cells.2 The mechanism of the growth promoting properties of caylin-1 have not yet been elucidated. |
性能| 供应商 | Cayman |
| 应用文献 |
1.Vassilev, L.T.,Vu, B.T.,Graves, B., et al. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science 303, 844-848 (2004).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 650.4 |
| 分子式 | C30H28Cl4N4O4 |
| CAS号 | 1207480-88-3 |
| 稳定性 | ≥ 2 years |
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