Caylin-2
货号：
10005002-10mg 基本售价：
5600.0 元 规格：
10 mg
产品信息
概述| 货号 | 10005002-10mg |
| 描述 | Nutlin-3 is an activator of p53 that functions by inhibiting the interaction of p53 with MDM2, a negative regulator of p53 activity.1 Caylin-2 is a nutlin-3 analog in which trifluoromethyl groups have been substituted for chlorine on the 2 phenyl rings. At high concentrations, caylin-2 inhibits the growth of HCT116 cells with an IC50 of approximately 8 µM, making it about 10-fold less potent than nutlin-3. Interestingly, at concentrations between 5-100 nM, caylin-2 promotes the growth of HCT116 cells approximately 40% compared to untreated cells.2 The mechanism of the growth promoting properties of caylin-2 have not yet been elucidated. |
性能| 供应商 | Cayman |
| 应用文献 |
1.Vassilev, L.T.,Vu, B.T.,Graves, B., et al. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science 303, 844-848 (2004).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 648.6 |
| 分子式 | C32H30F6N4O4 |
| CAS号 | 1392830-09-9 |
| 稳定性 | ≥ 1 year |
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