(+)-AS 115
货号：
10009650-1mg 基本售价：
5264.0 元 规格：
1 mg
产品信息
概述| 货号 | 10009650-1mg |
| 描述 | KIAA1363 is a 2-acetyl monoacylglyceryl ether (MAGE) hydrolase that is upregulated in aggressive cancers from various tissues.1 The enzyme catalyzes the hydrolysis of the 2-acetyl MAGE to MAGE and serves as a central enzyme in the PAF and LPA signaling network.2 AS 115 is a potent and selective inactivator of KIAA1363, displaying an IC50 value of 150 nM when tested as a racemic mixture in the invasive ovarian cancer cell line SKOV3.2 Treatment of SKOV3 cells with 10 µM AS-115 for 4 hours significantly reduced the formation of MAGE, alkyl-lysophosphatidylcholine, and alkyl-lysophosphatidic acid. The activity of the individual enantiomers of AS 115, i.e., (+)-AS 115 and (−)-AS 115, has not been determined. |
性能| 供应商 | Cayman |
| 应用文献 |
1.Jessani, N.,Liu, Y.,Humphrey, M., et al. Enzyme activity profiles of the secreted and membrane proteome that depict cancer cell invasiveness. Proceedings of the National Academy of Sciences of the United States of America 99(16), 10335-10340 (2002).
2.Chiang, K.P.,Niessen, S.,Saghatelian, A., et al. An enzyme that regulates ether lipid signaling pathways in cancer annotated by multidimensional profiling. Chemistry & Biology 13, 1041-1050 (2006).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 381.5 |
| 分子式 | C21H32FNO4 |
| 稳定性 | ≥ 1 year |
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