| 货号 | 10007207-100ug |
| 描述 | 12(S)-HETE is a product of arachidonic acid metabolism through the 12-lipoxygenase pathway. It is primarily found in platelets, leukocytes, and to a lesser extent in smooth muscle cells.1 It enhances tumor cell adhesion to endothelial cells, fibronectin, and the subendothelial matrix.2 tetranor-12(S)-HETE is the major β-oxidation product resulting from peroxisomal metabolism of 12(S)-HETE in numerous tissues, and Lewis lung carcinoma cells.3,4 No biological function has yet been determined for tetranor-12(S)-HETE. Some data indicate it may play a role in controlling the inflammatory response in injured corneas.4 In some diseases (e.g., Zellweger’s Syndrome) peroxisomal abnormalities result in the inability of cells to metabolize 12(S)-HETE, which may be responsible for symptoms of the disease. The tetranor derivative of 12(S)-HETE is available as a research tool for the elucidation of the metabolic fate of its parent compound. |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Evans, J.F.,Leblanc, Y.,Fitzsimmons, B.J., et al. Activation of leukocyte movement and displacement of [3H]leukotriene B4 from leukocyte membrane preparations by (12R)- and (12S)-hydroxyeicosatetraenoic acid. Biochimica et Biophysica Acta 917, 406-410 (1987). 2.Grossi, I.M.,Fitzgerald, L.A.,Umbarger, L.A., et al. Bidirectional control of membrane expression and/or activation of the tumor cell IRGpIIb/IIIa receptor and tumor cell adhesion by lipoxygenase products of arachidonic acid and linoleic acid. Cancer Research 49, 1029-1037 (1989). 3.Wigren, J.,Herbertsson, H.,Tollbom, Ö., et al. Metabolism of 12(S)-hydroxy-5,8,10,14-eicosatetraenoic acid by kidney and liver peroxisomes. Journal of Lipid Research 34, 625-631 (1993). 4.Hurst, J.S.,Bazan, H.P., and Balazy, M. The incorporation and release of 12(S)-hydroxyeicosatetraenoic acid and its major metabolite, 8(S)-hydroxyhexadecatrienoic acid, from rabbit corneal lipids. Experimental Eye Research 59, 97-106 (1994). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 266.4 |
| 分子式 | C16H26O3 |
| CAS号 | 121842-79-3 |
| 稳定性 | ≥ 1 year |
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