EUK 134
货号：
10006329-100mg 基本售价：
5040.0 元 规格：
100 mg
产品信息
概述| 货号 | 10006329-100mg |
| 描述 | Synthetic manganese-porphyrin complexes have been documented to act as scavengers for oxidative species such as peroxynitrite, superoxide, and hydrogen peroxide. EUK 134 is a salen-manganese complex that has been modified to increase its catalase activity while retaining SOD activity. EUK 134 is a salen-manganese complex that has been modified to increase its catalase activity while retaining SOD activity. EUK 134 consumes hydrogen peroxide with an initial reaction rate of 234 µM/min in vitro.1 EUK 134 is protective in a rat stroke model, employing middle cerebral artery ligation. At 2.5 mg/kg, rats treated with EUK 134 showed reduced infarct volume by more than 80%. EUK 134 at 10 mg/kg also significantly attenuates brain damage in rats following systemic administration of kainic acid.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Baker, K.,Marcus, C.B.,Huffman, K., et al. Synthetic combined superoxide dismutase/catalase mimetics are protective as a delayed treatment in a rat stroke model: A key role for reactive oxygen species in ischemic brain injury. Journal of Pharmacology and Experimental Therapeutics 284(1), 215-221 (1998).
2.Rong, Y.,Doctrow, S.R.,Tocco, G., et al. EUK-134, a synthetic superoxide dismutase and catalase mimetic, prevents oxidative stress and attenuates kainate-induced neuropathology. Proceedings of the National Academy of Sciences of the United States of America 96, 9897-9902 (1999).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 416.7 |
| 分子式 | C18H18ClMnN2O4 |
| CAS号 | 81065-76-1 |
| 稳定性 | ≥ 1 year |
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