| 货号 | 45120-1mg |
| 描述 | 9(S)-HpOTrE is a monohydroperoxy polyunsaturated fatty acid produced by the action of 5-lipoxygenase (5-LO) on α-linolenic acid.1 It can be further metabolized to colnelenic acid by a divinyl ether synthase activity found in garlic and potato microsomal fractions.2,3 9(S)-HpOTrE also serves as a substrate for further oxidation by both soybean and potato LOs, resulting in the formation of 9,16-dihydroperoxy acid.4,5 The suicide inactivation of LOs when 9(S)-HpOTrE is used as a substrate is thought to occur via formation of an unstable epoxide.6,7 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Galliard, T. and Phillips, D.R. Lipoxygenase from potato tubers. Partial purification and properties of an enzyme that specifically oxygenates the 9-position of linoleic acid. Biochemistry Journal 124, 431-438 (1971). 2.Crombie, L.,Morgan, D.O. and Smith, E.H. An isotopic study (2H and 18O) of the enzymic conversion of linoleic acid into colneleic acid with carbon chain fracture: The origin of shorter chain aldehydes. Journal of the Chemical Society.Perkin Transactions I 567-575 (1991). 3.Grechkin, A.N. and Hamberg, M. Divinyl ether synthase from garlic (Allium sativum L.) bulbs: Sub-cellular localization and substrate regio- and stereospecificity. FEBS Letters 388, 112-114 (1996). 4.Sok, D.E. and Kim, M.R. Enzymatic formation of 9,16-dihydro(pero)xyoctadecatrienoic acid isomers from α-linolenic acid. Archives of Biochemistry and Biophysics 277, 86-93 (1990). 5.Grechkin, A.N.,Kuramshin, R.A.,Safonova, E.Y., et al. Double hydroperoxidation of α-linolenic acid by potato tuber lipoxygenase. Biochimica et Biophysica Acta 1081, 79-84 (1991). 6.Sok, D.E. and Kim, M.R. The possible role of 9(S)-hydroperoxyoctadecatrienoic acid as a suicide substrate of soybean lipoxygenase. Biochemical and Biophysical Research Communications 162, 1357-1362 (1989). 7.Kim, M.R.,Kim, S.H. and Sok, D.E. Inactivation of potato lipoxygenase by hydroperoxy acids as suicide substrates. Biochemical and Biophysical Research Communications 164, 1384-1390 (1989). | |
| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 纯度 | ≥98% |
| 计算分子量 | 310.4 |
| 分子式 | C18H30O4 |
| CAS号 | 111004-08-1 |
| 稳定性 | ≥ 6 months |
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