CAY10444
货号：
10005033-50mg 基本售价：
4704.0 元 规格：
50 mg
产品信息
概述| 货号 | 10005033-50mg |
| 描述 | A family of related G-protein coupled receptors that bind sphingosine-1 phosphate (S1P) as a high-affinity ligand have recently been cloned.1,2S1P3/EDG3 is a member of this family that is widely expressed in many tissues, signaling via the ERK-½ and PLC/IP3 pathways. CAY10444 is a selective antagonist of S1P binding to the S1P3 receptor, blocking the calcium increase in HeLa cells by about 40% when present at 10 µM.3 |
| 别名 | BML-241; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Kluk, M.J., and Hla, T. Signaling of sphingosine-1-phosphate via the S1P/EDG-family of G-protein-coupled receptors. Biochimica et Biophysica Acta 1582, 72-80 (2002).
2.Chun, J.,Goetzl, E.J.,Hla, T., et al. International union of pharmacology. XXXIV. Lysophospholipid receptor nomenclature. Pharmacological Reviews 54, 265-269 (2002).
3.Koide, Y.,Hasegawa, T.,Takahashi, A., et al. Development of novel EDG3 antagonists using a 3D database search and their structure-activity relationships. Journal of Medicinal Chemistry 45, 4629-4638 (2002).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 287.5 |
| 分子式 | C15H29NO2S |
| CAS号 | 298186-80-8 |
| 稳定性 | ≥ 1 year |
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