| 货号 | 34360-25ug |
| 描述 | 8(S)-HETE is a major lipoxygenase product in PMA-treated murine epidermis.1 It activates mouse keratinocyte protein kinase C with an IC50 of 100 µM.2 8(S)-HETE also activates PPARα selectively at concentrations as low as 0.3 µM.3 Stereochemical assignment of the (S) enantiomer is based on comparison of chiral HPLC retention times to published results.4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Hughes, M.A., and Brash, A.R. Investigation of the mechanism of biosynthesis of 8-hydroxyeicosatetraenoic acid in mouse skin. Biochimica et Biophysica Acta 1081, 347-354 (1991). 2.Lo, H.H.,Bartek, G.A., and Fischer, S.M. In vitro activation of mouse skin protein kinase C by fatty acids and their hydroxylated metabolites. Lipids 29, 547-553 (1994). 3.Yu, K.,Bayona, W.,Kallen, C.B., et al. Differential activation of peroxisome proliferator-activated receptors by eicosanoids. The Journal of Biological Chemisty 270, 23975-23983 (1995). 4.Schneider, C.,Yu, Z.,Boeglin, W.E., et al. Enantiomeric separation of hydroxy and hydroperoxy eicosanoids by chiral column chromatography. Method.Enzymol. 433, 145-157 (2015). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 320.5 |
| 分子式 | C20H32O3 |
| CAS号 | 98462-03-4 |
| 稳定性 | ≥ 1 year |
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