StemMACS IWP-2
货号：
130-105-335 基本售价：
询价 规格：
EA
产品信息
概述| 货号 | 130-105-335 |
| 描述 | StemMACS™ IWP-2 is a selective small molecule inhibitor of Wnt signaling. |
性能| 供应商 | Miltenyi |
| 背景 | StemMACS™ IWP-2 inactivates the membrane-bound O-acyltransferase Porcupine (Porcn) which mediates palmitylation of Wnt proteins. Inhibition of Porcn prevents Wnt secretion and thus blocks activation of the Wnt signaling pathway. Consistent with the missing Wnt ligand, levels of phosphorylated Lrp6 and Dvl2 are decreased in the presence of IWP-2 and β-catenin cannot accumulate.1 |
