Oxidized Lipid HPLC Mixture
货号：
34004-1ea 基本售价：
1386.0 元 规格：
1 ea
产品信息
概述| 货号 | 34004-1ea |
| 描述 | This mixture contains the primary oxidized unsaturated fatty acid components of atherosclerotic plaques. Contents: (±)9-HODE, (±)13-HODE, (±)9-HODE cholesteryl ester, (±)13-HODE cholesteryl ester, and (±)15-HETE (5 µg each). Cholesterol and LDL particles accumulate and become oxidized in the fatty deposits of atherosclerotic placques. Contained within these lipid deposits are the racemic monohydroxylation products of both linoleic and arachidonic acid.1 This HPLC mixture contains the free acid (non-esterified) forms of racemic 15-HETE, 9-HODE, and 13-HODE. 15-HETE is one of 5 different regioisomers produced by the random oxygenation of arachidonic acid.2 (The other 4 can be purchased in HPLC Mixture Catalog. No. 34002.) The 9- and 13- HODEs are the 2 different monohydroxylated regioisomers of linoleic acid produced during random free radical oxidation. In this mixture, the HODE compounds are provided both in their free acid form, and also esterified to cholesterol. Linoleate is transported primarily as the cholesteryl ester in the LDL particle, and it is likely that the esterified form is oxidized when LDL particles are exposed to uncontrolled reactive oxygen species.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Belkner, J.,Wiesner, R.,Kühn, H., et al. The oxygenation of cholesterol esters by the reticulocyte lipoxygenase. FEBS Letters 279, 110-114 (1991).
2.Green, M.D.,Xiao, L., and Lal, A.A. Formation of hydroxyeicosatetraenoic acids from hemozoin-catalyzed oxidation of arachidonic acid. Molecular and Biochemical Parasitology 83, 183-188 (1996).
3.Harland, W.A.,Gilbert, J.D., and Brooks, C.J.W. Lipids of Human Atheroma. VIII. Oxidised derivatives of cholesteryl linoleate. Biochimica et Biophysica Acta 316, 378-385 (1973).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | >98% for each compound |
| 稳定性 | ≥ 1 year |
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