| 货号 | 34710-25ug |
| 描述 | 15(R)-HETE is produced when aspirin-inhibited COX-2 is incubated with arachidonic acid.1,2 The clinical significance of 15(R)-HETE and its potential downstream metabolites is the subject of current investigations.3,4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Lecomte, M.,Laneuville, O.,Ji, C., et al. Acetylation of human prostaglandin endoperoxide synthase-2 (cyclooxygenase-2) by aspirin. The Journal of Biological Chemisty 269, 13207-13215 (1994). 2.Capdevila, J.H.,Morrow, J.D.,Belosludtsev, Y.Y., et al. The catalytic outcomes of the constitutive and the mitogen inducible isoforms of prostaglandin H2 synthase are markedly affected by glutathione and glutathione peroxidase(s). Biochemistry 34, 3325-3337 (1995). 3.Clària, J.,Lee, M.H., and Serhan, C.N. Aspirin-triggered lipoxins (15-epi-LX) are generated by the human lung adenocarcinoma cell line (A549)-neutrophil interactions and are potent inhibitors of cell proliferation. Molecular Medicine 2, 583-596 (1996). 4.Levy, B.D.,De Sanctis, G.T.,Devchand, P.R., et al. Multi-pronged inhibition of airway hyper-responsiveness and inflammation by lipoxin A4. Nature Medicine 8(9), 1018-1023 (2002). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 320.5 |
| 分子式 | C20H32O3 |
| CAS号 | 83603-31-0 |
| 稳定性 | ≥ 2 years |
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