| 货号 | 14091 |
| 描述 | RVX-208 is a potent BET bromodomain antagonist with (IC50 = 0.51 µM for BD2) with approximately 170-fold selectivity over BD1 (ref 1,2). Increases apolipoprotein A-1 and HDL cholesterol in vitroandin vivo (ref 3). Reduces atherosclerosis (ref 4). |
| 供应商 | Active Motif |
| 运输条件 | Blue Ice |
| 存放说明 | Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 1 month. |
| 纯度 | >98% (TLC); NMR (Conforms) |
| 计算分子量 | 370.4 |
| 分子式 | C20H22N2O5 |
| CAS号 | 1044870-39-4 |
| 外观 | White powder. May be dissolved in DMSO (75 mg/ml); Ethanol (4 mg/ml). |
| 参考文献 | 1. S Picaud et al. Proc. Natl. Acad. Sci. USA 2013, 110:19754 2. KG McLure et al. PLoS One 2013, 8:e83190 3. D Bailey et al. J. Am. Coll. Cardiol. 2010, 55:2580 4. R Jahagirdar et al. Atherosclerosis 2014, 236:91 |
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Chemical structure of RVX-208. |
