| 货号 | 35260-25ug |
| 描述 | 5(S),12(S)-DiHETE is a natural bioactive lipid derived from arachidonic acid (AA; Item No. 10006607). It is synthesized by glycogen-induced rabbit peritoneal polymorphonuclear leukocytes (PMNLs) incubated with AA.1 5(S),12(S)-DiHETE can be produced by successive oxygenation of AA by 5-lipoxygenase (5-LO) in platelets and 12-LO in leukocytes.2 It can also be synthesized from 12(S)-HETE by 5-LO, in the presence of 5-LO activating protein (FLAP), activated with calcium ionophore.3 5(S),12(S)-DiHETE is an epimer of leukotriene B4 (Item No. 20110) that is weakly chemotactic for PMNL.4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Borgeat, P. and Samuelsson, B. Metabolism of arachidonic acid in polymorphonuclear leukocytes. J. Biol. Chem. 254, 7865-7869 (1979). 2.Borgeat, P.,Fruteau De Laclos, B.,Picard, S., et al. Studies on the mechanism of formation of the 5S,12S-dihydroxy-6,8,10,14 (E,Z,E,Z)-eicosatetraenoic acid in leukocytes. Prostaglandins 23, 713-724 (1982). 3.Mancini, J.A.,Waterman, H. and Riendeau, D. Cellular oxygenation of 12-hydroxyeicosatetraenoic acid and 15-hydroxyeicosatetraenoic acid by 5-lipoxygenase is stimulated by 5-lipoxygenase-activating protein. J. Biol. Chem. 273, 32842-32847 (1998). 4.Lee, T.H.,Mencia-Huerta, J.M.,Shih, C., et al. Characterization and biologic properties of 5,12-dihydroxy derivatives of eicosapentaenoic acid, including leukotriene B5 and the double lipoxygenase product. J. Biol. Chem. 259, 2383-2389 (1984). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 336.5 |
| 分子式 | C20H32O4 |
| CAS号 | 79056-01-2 |
| 稳定性 | ≥ 1 year |
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