| 货号 | 10005-1ea |
| 描述 | This mixture contains the primary metabolites of prostaglandins (PGs) D2, E2, and F2α. Contents: 13,14-dihydro-15-keto PGD2, 13,14-dihydro-15-keto PGE2, 11β-PGF2α, 13,14-dihydro-15-keto PGF2α, and PGF2β (100 µg each). In primates, the lung is an active site of PG inactivation via 15-hydroxy PG dehydrogenase (15-hydroxy PGDH).1 E and F-series PGs are good substrates for 15-hydroxy PGDH, which oxidizes the C-15 hydroxyl group to give the corresponding 15-keto compounds.2 This oxidation if followed rapidly by Δ13-reductase removal of the 13,14-double bond, to give 13,14-dihydro-15-keto PG metabolites.3 While the primary PGs are often undetectable in plasma due to their rapid inactivation, the 13,14-dihydro-15-keto metabolites can be present at concentrations of several hundred pg/ml.4 In addition, 9- and 11-keto PG-reductases have been reported, especially in the case of PGD2, which produce F-series PG metabolites with a β-hydroxyl group on the ring.5 These metabolites span a wide polarity range and separate well on reversed phase HPLC. |
| 别名 | PG Metabolite HPLC Mixture; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Hansen, H.S. 15-Hydroxyprostaglandin dehydrogenase. A review. Prostaglandins 12, 647-679 (1976). 2.Sun, F.F.,Armour, S.B.,Bockstanz, V.R., et al. Studies on 15-hydroxyprostaglandin dehydrogenase from monkey lung. Advances in Prostaglandin and Thromboxane Research 1, 163-169 (1976). 3.Basu, S., and Stjernschantz, J. Δ13-reductase dependent metabolism of prostaglandins in the mammalian brain and eye. Prostaglandins, Leukotrienes and Essential Fatty Acids 57, 305-310 (1997). 4.Granström, E.,Hamberg, M.,Hansson, G., et al. Chemical instability of 15-keto-13,14-dihydro-PGE2: The reason for low assay reliability. Prostaglandins 19, 933-945 (1980). 5.Ellis, C.K.,Smigel, M.D.,Oates, J.A., et al. Metabolism of prostaglandin D2 in the monkey. The Journal of Biological Chemisty 254, 4152-4163 (1979). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | >98% for each compound |
| 稳定性 | ≥ 6 months |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |