| 货号 | 10000-1ea |
| 描述 | This mixture contains all of the major UV-absorbing cyclopentenone prostaglandins and their precursors. Contents: 100 µg of each compound Prostaglandin A2 (Item No. 10210) Prostaglandin B2 (Item No. 11210) Prostaglandin D2 (Item No. 12010) Prostaglandin E2 (Item No. 14010) Prostaglandin J2 (Item No. 18500) 15-deoxy-Δ12,14-Prostaglandin J2 (Item No. 18570) PGE2 and PGD2 are both chemically unstable. In the absence of any enzymatic influence, both are undergo dehydration to form the highly UV active cyclopentenone compounds PGA2 and PGJ2, respectively.1,2 These compounds absorb in the ultraviolet with maxima at 216 - 220 lambda. The cyclopentenone prostaglandins have been noted to have antimitotic, antiviral and antitumor activity in a number of systems.3,4PGA2 and PGJ2, can also undergo further elimination and double bond rearrangements to give PGB2 and 15-deoxy-Δ12,14PGJ2, respectively. 15-deoxy-Δ12,14PGJ2 is a relatively potent ligand for the PPARγ nuclear receptor. PGB2 does not appear to have significant intrinsic biological activity; however, it is frequently used as a reliable internal standard for analysis of eicosanoids by HPLC. |
| 别名 | Cyclopentenone PG HPLC Mixture; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Granström, E., and Samuelsson, B. Quantitative measurement of prostaglandins and thromboxanes: General considerations. Advances in Prostaglandin and Thromboxane Research 5, 1-13 (1978). 2.Fitzpatrick, F.A., and Wynalda, M.A. Albumin-catalyzed metabolism of prostaglandin D2. Identification of products formed in vitro. The Journal of Biological Chemisty 258, 11713-11718 (1983). 3.Fukushima, M.,Kato, T.,Narumiya, S., et al. Prostaglandin A and J: Antitumor and antiviral prostaglandins. Advances in Prostaglandin, Thromboxane, and Leukotriene Research 19, 415-418 (1989). 4.Fukushima, M. Prostaglandin J2 - antitumor and anti-viral activities and the mechanisms involved. Eicosanoids 3, 189-199 (1990). | |
| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 纯度 | ≥98% for each compound |
| 稳定性 | ≥ 6 months |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |