14(15)-EET-SI
货号：
10009286-25ug 基本售价：
910.0 元 规格：
25 ug
产品信息
概述| 货号 | 10009286-25ug |
| 描述 | Arachidonic acid is metabolized in the vascular endothelium to epoxytrienoic acids (EETs or EpETrEs) by cytochrome P450 enzymes. The EETs are released in response to acetylcholine, bradykinin, arachidonic acid, or cyclic stretch.1 14(15)-EET-SI is the methyl sulfonamide analog of 14(15)-EET. This substitution results in a metabolically more stable compound because it is not sensitive to β-oxidation or membrane esterification. 14(15)-EET-SI is equipotent to 14(15)-EET in vascular agonist activity as measured by relaxation of precontracted bovine coronary arteries.1 In addition, 14(15)-EET and the methyl sulfonamide analog both stimulate tyrosine phosphorylation and induce mitogenesis in renal epithelial cells.2 |
| 别名 | 14(15)-EpETrE-SI;14(15)-EET-sulfonimide; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Gauthier, K.M.,Falck, J.R.,Reddy, L.M., et al. 14,15-EET analogs: Characterization of structural requirements for agonist and antagonist activity in bovine coronary arteries. Pharmacological Research 49, 515-524 (2004).
2.Chen, J.K.,Falck, J.R.,Reddy, K.M., et al. Epoxyeicosatrienoic acids and their sulfonimide derivatives stimulate tyrosine phosphorylation and induce mitogenesis in renal epithelial cells. The Journal of Biological Chemisty 273(44), 29254-29261 (1998).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 397.6 |
| 分子式 | C21H35NO4S |
| CAS号 | 218461-97-3 |
| 稳定性 | ≥ 1 year |
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