| 货号 | 10006593-50ug |
| 描述 | Prostaglandin D synthase (PGD synthase) catalyzes the isomerization of PGH2 to produce PGD2. PGD2 induces sleep, regulates nociception, inhibits platelet aggregation, and acts as an allergic mediator. Two distinct types of PGD synthase have been identified, namely the lipocalin-type enzyme (β-trace) and the hematopoietic enzyme.1,2,3,4 Hematopoietic PGD synthase (H-PGDS) is widely distributed in the peripheral tissues and is localized in the antigen-presenting cells, mast cells, and megakaryocytes. PGD2 is produced by H-PGDS in large quantities by allergen-stimulated mast cells and acts as a pro-inflammatory mediator in allergic reactions. H-PGDS requires glutathione for activity and belongs to the sigma-class of glutathione-S-transferases.1,4,5 Cayman Chemical’s H-PGDS is a highly-purified, active recombinant enzyme isolated from an E. Coli expression system. The enzyme is ideally suited for a variety of biochemical experiments including mechanistic studies and development of selective enzyme inhibitors. |
| 别名 | H-PGDS;Hematopoietic-PGDS;PGD Synthase (hematopoietic-type; human recombinant); |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Kanaoka, Y.,Fujimori, K.,Kikuno, R., et al. Structure and chromosomal localization of human and mouse genes for hematopoietic prostaglandin D synthase. European Journal of Biochemistry 267, 3315-3322 (2000). 2.Jowsey, I.R.,Thomson, A.M.,Flanagan, J.U., et al. Mammalian class sigma glutathione s-transferases: Catalytic properties and tissue-specific expression of human and rat GSH-dependent prostaglandin D2 synthases. Biochemistry Journal 359, 507-516 (2001). 3.Urade, Y.,Watanabe, K., and Hayaishi, O. Prostaglandin D, E, and F synthases. Journal of Lipid Mediators and Cell Signalling 12, 257-273 (1995). 4.Kanaoka, Y.,Ago, H.,Inagaki, E., et al. Cloning and crystal structure of hematopoietic prostaglandin D synthase. Cell 90, 1085-1095 (1997). 5.Urade, Y.,Fujimoto, N.,Ujihara, M., et al. Biochemical and immunological characterization of rat spleen prostaglandin D synthetase. The Journal of Biological Chemisty 262(8), 3820-3825 (1987). | |
| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 纯度 | ≥95% estimated by SDS-PAGE |
| 稳定性 | ≥ 6 months |
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