PD 169316
货号：
10006727-1mg 基本售价：
686.0 元 规格：
1 mg
产品信息
概述| 货号 | 10006727-1mg |
| 描述 | p38 is a member of the mitogen-activated protein kinase (MAPK) superfamily of enzymes that play an important role in signal transduction. PD 169316 is a selective inhibitor of p38 MAPK.1 It inhibits p38 MAPK with an IC50 of 89 nM, whereas the IC50s are >100-fold higher for extracellular signal-regulated kinase (ERK) and >1,000-fold higher for protein kinase A (PKA) and PKCα.1 PD 169316 inhibits apoptosis of neuronal and non-neuronal cells deprived of specific trophic factors such as potassium or nerve growth factor.2,3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Gallagher, T.F.,Seibel, G.L.,Kassis, S., et al. Regulation of stress-induced cytokine production by pyridinylimidazoles; Inhibition of CSBP kinase. Bioorganic & Medicinal Chemistry 5(1), 49-64 (1997).
2.Nath, R.,McGinnis, K.,Dutta, S., et al. Inhibition of p38 kinase mimics survival signal-linked protection against apoptosis in rat cerebellar granule neurons. Cellular and Molecular Biology Letters 6, 173-184 (2001).
3.Kummer, J.L.,Rao, P.K., and Heidenreich, K.A. Apoptosis induced by withdrawal of trophic factors is mediated by p38 mitogen-activated protein kinase. The Journal of Biological Chemisty 272(33), 20490-20494 (1997).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | >98% |
| 计算分子量 | 360.3 |
| 分子式 | C20H13FN4O2 |
| CAS号 | 152121-53-4 |
| 稳定性 | ≥ 2 years |
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