PD 169316
货号:
10006727-1mg 基本售价:
686.0 元 规格:
1 mg
产品信息
概述货号 | 10006727-1mg |
描述 | p38 is a member of the mitogen-activated protein kinase (MAPK) superfamily of enzymes that play an important role in signal transduction. PD 169316 is a selective inhibitor of p38 MAPK.1 It inhibits p38 MAPK with an IC50 of 89 nM, whereas the IC50s are >100-fold higher for extracellular signal-regulated kinase (ERK) and >1,000-fold higher for protein kinase A (PKA) and PKCα.1 PD 169316 inhibits apoptosis of neuronal and non-neuronal cells deprived of specific trophic factors such as potassium or nerve growth factor.2,3 |
性能供应商 | Cayman |
应用文献 |
1.Gallagher, T.F.,Seibel, G.L.,Kassis, S., et al. Regulation of stress-induced cytokine production by pyridinylimidazoles; Inhibition of CSBP kinase. Bioorganic & Medicinal Chemistry 5(1), 49-64 (1997). 2.Nath, R.,McGinnis, K.,Dutta, S., et al. Inhibition of p38 kinase mimics survival signal-linked protection against apoptosis in rat cerebellar granule neurons. Cellular and Molecular Biology Letters 6, 173-184 (2001). 3.Kummer, J.L.,Rao, P.K., and Heidenreich, K.A. Apoptosis induced by withdrawal of trophic factors is mediated by p38 mitogen-activated protein kinase. The Journal of Biological Chemisty 272(33), 20490-20494 (1997).
|
运输条件 | Room temperature in continental US; may vary elsewhere |
存放说明 | -20 |
纯度 | >98% |
计算分子量 | 360.3 |
分子式 | C20H13FN4O2 |
CAS号 | 152121-53-4 |
稳定性 | ≥ 2 years |
声明本官网所有报价均为常温或者蓝冰运输价格,如有产品需要干冰运输,需另外加收干冰运输费。 |