(±)5-HEPE
货号：
32200-25ug 基本售价：
630.0 元 规格：
25 ug
产品信息
概述| 货号 | 32200-25ug |
| 描述 | (±)5-HEPE is produced by non-enzymatic oxidation of EPA. It contains equal amounts of 5(S)-HEPE and 5(R)-HEPE. The biological activity of (±)5-HEPE is likely mediated by one of the individual isomers, most commonly the 5(S) isomer in mammalian systems. EPA can be metabolized to 5-HEPE in human and bovine neutrophils, and human eosinophils, which is further metabolized to 5-oxoEPE and LTB5.1,2,3 The 5-series metabolites of EPA, namely 5-HEPE, 5-oxoEPE, and LTB5, have significantly decreased biological effects compared to the arachidonic acid-derived metabolites.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Powell, W.S.,Gravel, S., and Gravelle, F. Formation of a 5-oxo metabolite of 5,8,11,14,17-eicosapentaenoic acid and its effects on human neutrophils and eosinophils. Journal of Lipid Research 36, 2590-2598 (1995).
2.Lee, T.H.,Mencia-Huerta, J.M.,Shih, C., et al. Effects of exogenous arachidonic, eicosapentaenoic, and docosahexaenoic acids on the generation of 5-lipoxygenase pathway products by ionophore-activated human neutrophils. Journal of Clinical Investigation 74, 1922-1933 (1984).
3.Taylor, S.M.,Laegreid, W.W.,Heidel, J.R., et al. EArachidonic and eicosapentaenoic acid metabolism in bovine neutrophils and platelets: Effect of calcium ionophore. Journal of Leukocyte Biology 42, 253-262 (1987).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥97% |
| 计算分子量 | 318.5 |
| 分子式 | C20H30O3 |
| CAS号 | 83952-40-3 |
| 稳定性 | ≥ 1 year |
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