| 货号 | 10006726-5mg |
| 描述 | Mitogen-activated protein kinases (MAPK) are a family of serine/threonine protein kinases that are involved in many cellular programs such as cell proliferation, cell differentiation, cell movement, and cell death.1,2,3 PD 98059 is a selective noncompetitive inhibitor of the mitogen-activated protein kinases (MAPK) pathway.4,5 It prevents the activation of MAPKK1 by Raf or MEK kinase (a MAPKKK) with an IC50 value of 2-7 µM but does not inhibit Raf-activated MAPKK1.6 PD 98059 inhibits Raf activation of MAPKK2 less effectively with an IC50 value of 50 µM.6 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Vojtek, A.B., and Der, C.J. Increasing complexity of the Ras signaling pathway. The Journal of Biological Chemisty 273, 19925-19928 (1998). 2.Marinissen, M.J., and Gutkind, J.S. G-protein-coupled receptors and signaling networks: Emerging paradigms. Trends in Pharamacological Sciences 22(7), 368-376 (2001). 3.Gutkind, J.S. The pathways connecting G protein-coupled receptors to the nucleus through divergent mitogen-activated protein kinase cascades. The Journal of Biological Chemisty 273, 1839-1842 (1998). 4.Davies, S.P.,Reddy, H.,Caivano, M., et al. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochemistry Journal 351, 95-105 (2000). 5.Dudley, D.T.,Pang, L.,Decker, S.J., et al. A synthetic inhibitor of the mitogen-activated protein kinase cascade. Proceedings of the National Academy of Sciences of the United States of America 92, 7686-7689 (1995). 6.Alessi, D.R.,Cuenda, A.,Cohen, P., et al. PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. The Journal of Biological Chemisty 270(46), 27489-27494 (1995). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 267.3 |
| 分子式 | C16H13NO3 |
| CAS号 | 167869-21-8 |
| 稳定性 | ≥ 2 years |
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