| 货号 | 33300-25ug |
| 描述 | (±)7-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro.1,2 It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes.3,4,5 Enzymatic transformation of DHA by RBL-1 cells and human neutrophils also produces 7-HDHA.6,7 However, the enzymatic product is most likely the S-isomer. (±)7-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant polyunsaturated fatty acid. |
| 别名 | 7-hydroxy Docosahexaenoic Acid;(±)7-HDoHE; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.VanRollins, M. and Murphy, R.C. Autooxidation of docosahexaenoic acid: Analysis of ten isomers of hydroxydocosahexaenoate. J. Lipid Res. 25(5), 507-517 (1984). 2.Reynaud, D.,Thickitt, C.P. and Pace-Asciak, C.R. Facile preparation and structural determination of monohydroxy derivatives of docosahexaenoic acid (HDoHE) by α-tocopherol-directed autoxidation. Anal. Biochem. 214(1), 165-170 (1993). 3.VanRollins, M.,Baker, R.C.,Sprecher, H., et al. Oxidation of docosahexaenoic acid by rat liver microsomes. J. Biol. Chem. 259(9), 5776-5783 (1984). 4.Yamane, M.,Abe, A. and Yamane, S. High-performance liquid chromatography-thermospray mass spectrometry of epoxy polyunsaturated fatty acids and epoxyhydroxy polyunsaturated fatty acids from an incubation mixture of rat tissue homogenate. J. Chromatogr. 652(2), 123-136 (1994). 5.Kim, H.Y.,Karanian, J.W.,Shingu, T., et al. Sterochemical analysis of hydroxylated docosahexaenoates produced by human platelets and rat brain homogenate. Prostaglandins 40(5), 473-490 (1990). 6.Corey, E.J.,Shih, C. and Cashman, J.R. Docosahexaenoic acid is a strong inhibitor of prostaglandin but not leukotriene biosynthesis. Proceedings of the National Academy of Sciences of the United States of America 80, 3581-3584 (1983). 7.Fischer, S.,Schacky, C.V.,Siess, W., et al. Uptake, release and metabolism of docosahexaenoic acid (DHA, C22:6ω3) in human platelets and neutrophils. Biochemical and Biophysical Research Communications 120, 907-918 (1984). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 344.5 |
| 分子式 | C22H32O3 |
| CAS号 | 90780-55-5 |
| 稳定性 | ≥ 2 years |
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