(±)-C75
货号：
10005270-1mg 基本售价：
616.0 元 规格：
1 mg
产品信息
概述| 货号 | 10005270-1mg |
| 描述 | Inhibition of fatty acid synthase (FAS) by the irreversible inhibitor cerulenin leads to cytotoxicity and apoptosis in human cancer cell lines.1 (±)-C75 is a stable inhibitor of FAS that leads to profound weight loss and feeding inhibition in both high-fat diet wild type obese and leptin-deficient ob/obmice.2 (±)-C75 is also cytotoxic to many human cancer cell lines, an effect believed to be mediated by the accumulation of malonyl-coenzyme A in cells with an upregulated FAS pathway.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Moche, M.,Schneider, G.,Edwards, P., et al. Structure of the complex between the antibiotic cerulenin and its target, β-ketoacyl-acyl carrier protein synthase. The Journal of Biological Chemisty 274(10), 6031-6034 (1999).
2.Loftus, T.M.,Jaworsky, D.E.,Frehywot, G.L., et al. Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors. Science 288, 2379-2381 (2000).
3.Pizer, E.S.,Thupari, J.,Han, W.F., et al. Malonyl-coenzyme-A is a potential mediator of cytotoxicity induced by fatty-acid synthase inhibition in human breast cancer cells and xenografts. Cancer Research 60, 213-218 (2000).
|
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 254.3 |
| 分子式 | C14H22O4 |
| CAS号 | 191282-48-1 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
